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Wade Wilson also famous as Dedpul, travels all over the world and exterminates criminal clans. In one day to it several bandits home rush and kill Vanessa, the hero's beloved. Dedpul cannot reconcile to this loss and forgive himself for the fact that could not protect the girl. He over and over again tries to commit suicide, but unsuccessfully. After explosion in Wade Koloss's apartment carries pieces of his body to Ickx's Mansion. There Dedpul is completely regenerated.

In the same time from the future to the world of the present the cyborg soldier Keybl whose family died after the provoked explosion of their house is. He tries to prevent accident and looks for future murderer. The boy mutant by the name of Russell, it Fayrfist injured by ill treatment in "The center of re-education" appears them. It is embittered and in the desire to revenge offenders ceases to control the improbable force. Keybl is to the location of Russell where by accident there is also Dedpul. The fight is started, Wade protects the boy from the soldier from the future, before it having already killed the worker-sadist from the center of re-education. Both get to prison for mutants, but soon Dedpulu is possible to run away from there. Russell remains there. Keybl continues the hunting, and the cheerful mercenary gathers a team to save the boy. However none of participants of this history even represent what enemy all of them should meet.